The present investigation highlights the formulation, optimization and evaluation of gastroretentive effervescent floating tablets of diltiazem HCl employing tamarind kernel gum. Diltiazem hydrochloride (DTZ) is a calcium channel blocker belonging to the benzothiazepine family, widely used in the treatment of hypertension and angina. Due to its short half life (3.5 h) and absorption in the upper gastrointestinal region, it can be formulated into gastroretentive floating tablets for prolonged release of the drug and better absorption. The objective of the present investigation was to develop a new floating polysaccharide polymer i.e., tamarind kernel gum and optimizing the concentration of it in the formulation of floating tablets, along with the concentrations of the sodium bicarbonate (gas generating agent) and ethyl cellulose (floating enhancer) by using 23 factorial design.
Loading....